Endocrine Abstracts

Background: The aim of this study was to assess health-related quality of life (HRQoL) of patients living in cities and towns with different population in the Russian Federation (RF) using EQ-5D questionnaire, to calculate health utility index (QALY) and cost-utility ratio (CUR).Methods: One of the goals of the multicenter, observational, epidemiologic study FORSIGHT-DM2 was to evaluate HRQoL using the EQ-5D Questionnaire. The study included more than 20...

Aim: The aim of our study was to assess the contribution of genetic variation in some previously reported gestational diabetes mellitus (GDM) susceptibility loci and lifestyle parameters to GDM risk.Methods: We performed a case-control study of 278 GDM cases and 179 controls who had filled up special questionnaires concerning their lifestyle habits during the oral glucose tolerance test (OGTT) on the 24–32 week of gestation. The questionnaire consis...

Introduction: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. Identification of early determinants of GDM is necesary to designate possible preventive strategies. The aim of this study was to reveal the most significant risk factors for GDM.Design: A total of 209 women with singleton pregnancies were included in the study. Maternal fasting glucose, anthropometric parameters and blood pressure were measured in the first trimeste...

Background: Understanding the mechanism whereby the intrauterine hyperglycemia in women with gestational diabetes mellitus (GDM) affects the offspring’ predisposition to metabolic and cardiovascular diseases may help prevent their intergenerational transmission. Our aim was to study the effect of the degree and duration of maternal hyperglycemia on the level of expression of genes associated with cardio-metabolic diseases in human umbilical vein endothelial cells (HUVECs)...